Research and Development
AT ALKEM ACTIVA
Our R&D department at Alkem Activa is at the forefront of Active Pharmaceutical Ingredient (API) development, driving advancements in pharmaceutical science and healthcare. Here's a closer look at our API development initiatives
Every project undertaken by our R&D team is anchored in a commitment to reliability, ensuring consistency and excellence. In order to prevent the existence of nitrosamine impurities, our team of R&D professionals created processes and analytical methods that are already suitable to confirm future requirements of the EMA.
We have sophisticated instruments like Bruker Nuclear Magnetic Resonance (NMR), triple quad Liquid Chromatography with tandem mass spectrometry (LCMSMS), Gas Chromatography-Tandem Mass Spectrometry (GCMSMS), X-ray crystallography (XRD), High-performance liquid chromatography (HPLC), Ion chromatograph, Differential scanning calorimetry (DSC) and Thermogravimetric analyzers (TGA)
A state-of-the-art facility with advanced chemical synthesis labs, analytical development labs, kilo lab, high pressure lab and safety study lab.
A team of qualified, well trained and dedicated scientists specialize in developing innovative processes/technologies with global regulatory requirements
Our strong expertise in QbD (Quality by design) & DoE (Design of Experiments) enables us to increase process robustness and ease scale-up at plant
- Asymmetric Synthesis/Chiral Resolution
- High Pressure Reactions (For example, Hydrogenation, Hydrogenolysis Ammonolysis etc)
- Enzymatic Reactions
- Coupling Reactions using Organometallic Catalyst
- Oxidation
- Reduction
- Alkylation/Acylation
- Bromination
- Nitration
- Condensation Reactions
- Cryogenic Reactions (For Example, reaction using strong base like BuLi, LDA, NaH etc)
- Esterification / Transesterifcation / Hydrolysis and many other reactions